Research Technician II Job at Aequor, South San Francisco, CA

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  • Aequor
  • South San Francisco, CA

Job Description

Job Title : Research Technician II

Location : South San Francisco, CA 94080 (fully on-site)

Duration : Until 11/23/2026

Interview Format : Virtual (Three rounds)



Department : Structural Biology, Protein Sciences



The opportunity
  • We are seeking a motivated scientist interested in using structural biology to understand the molecular mechanisms of large macromolecular complexes involved in DNA repair processes.
  • The role involves protein purification, reconstitution, and structure determination of DNA-protein complexes using cryoEM.
  • Additionally, you will help to develop functional biochemical assays to assess and determine the mechanism of action of various multi-subunit protein complexes.
  • You will be highly encouraged to think deeply about the biological problem, make significant intellectual contributions to the chosen research project, and work closely with other team members.
  • It is an exceptional opportunity to pursue basic and drug-discovery questions in a well-resourced biotechnology environment.


Qualifications
  • BS/MS degree with 3-5 years of experience or a PhD with 0-2 years of experience in Biochemistry, Chemical Biology, Structural Biology, or a related discipline.
  • Hands-on experience designing and optimizing the purification of challenging protein targets (including protein complexes) for structural and/or functional studies.
  • Development of functional biochemical and biophysical assays.
  • Experience in cryoEM sample and grid preparation (beneficial qualification).
  • Experience with mammalian cell culture functional assays (beneficial qualification)


Requirements
  • The role involves Protein Purification, Reconstitution, and Structure Determination of DNA-protein complexes using cryoEM.
  • To Develop functional Biochemical Assays to assess and determine the mechanism of action of various Multi-Subunit Protein complexes.
  • BS/MS degree with 3-5 years of experience or a PhD with 0-2 years of experience in Biochemistry, Chemical Biology, Structural Biology.

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